Comparative analysis of the base biases at the gene terminal portions in seven eukaryote genomes.

ABSTRACT: Adenine nucleotides have been found to appear preferentially in the regions after the initiation codons or before the termination codons of bacterial genes. Our previous experiments showed that AAA and AAT, the two most frequent second codons in Escherichia coli, significantly enhance translation efficiency. To determine whether such a characteristic feature of base frequencies exists in eukaryote genes, we performed a comparative analysis of the base biases at the gene terminal portions using the proteomes of seven eukaryotes. Here we show that the base appearance at the codon third positions of gene terminal regions is highly biased in eukaryote genomes, although the codon third positions are almost free from amino acid preference. The bias changes depending on its position in a gene, an

SUBMITTER: Niimura Y 

PROVIDER: S-EPMC212801 | biostudies-literature | 2003 Sep

REPOSITORIES: biostudies-literature