Long term pharmacotherapy for obesity and overweight: updated meta-analysis.

ABSTRACT:

Objective

To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status.

Design

Updated meta-analysis of randomised trials.

Data sources

Medline, Embase, the Cochrane controlled trials register, the Current Science meta-register of controlled trials, and reference lists of identified articles. All data sources were searched from December 2002 (end date of last search) to December 2006.

Studies reviewed

Double blind randomised placebo controlled trials of approved anti-obesity drugs used in adults (age over 18) for one year or longer.

Results

30 trials of one to four years' duration met the inclusion criteria: 16 orlistat (n=10 631 participants), 10 sibutramine (n=2623), and four rimonabant (n=6365). Of these, 14

SUBMITTER: Rucker D 

PROVIDER: S-EPMC2128668 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature