Canine population structure: assessment and impact of intra-breed stratification on SNP-based association studies.

ABSTRACT:

Background

In canine genetics, the impact of population structure on whole genome association studies is typically addressed by sampling approximately equal numbers of cases and controls from dogs of a single breed, usually from the same country or geographic area. However one way to increase the power of genetic studies is to sample individuals of the same breed but from different geographic areas, with the expectation that independent meiotic events will have shortened the presumed ancestral haplotype around the mutation differently. Little is known, however, about genetic variation among dogs of the same breed collected from different geographic regions.

Methodology/principal findings

In this report, we address the magnitude and impact of genetic diversity among common br

SUBMITTER: Quignon P 

PROVIDER: S-EPMC2129117 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature