Localization of candidate regions maintaining a common polymorphic inversion (2La) in Anopheles gambiae.

ABSTRACT: Chromosomal inversion polymorphisms are thought to play a role in adaptive divergence, but the genes conferring adaptive benefits remain elusive. Here we study 2La, a common polymorphic inversion in the African malaria vector Anopheles gambiae. The frequency of 2La varies clinally and seasonally in a pattern suggesting response to selection for aridity tolerance. By hybridizing genomic DNA from individual mosquitoes to oligonucleotide microarrays, we obtained a complete map of differentiation across the A. gambiae genome. Comparing mosquitoes homozygous for the 2La gene arrangement or its alternative (2L+(a)), divergence was highest at loci within the rearranged region. In the 22 Mb included within alternative arrangements, two approximately 1.5 Mb regions near but not adjacent to the brea

SUBMITTER: White BJ 

PROVIDER: S-EPMC2134946 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature