Antithrombin III in critically ill patients: systematic review with meta-analysis and trial sequential analysis.

ABSTRACT:

Objective

To evaluate the benefits and harms of antithrombin III in critically ill patients.

Design

Systematic review and meta-analysis of randomised trials.

Data sources

CENTRAL, Medline, Embase, International Web of Science, LILACS, the Chinese Biomedical Literature Database, and CINHAL (to November 2006); hand search of reference lists, contact with authors and experts, and search of registers of ongoing trials.

Review methods

Two reviewers independently selected parallel group randomised clinical trials comparing antithrombin with placebo or no intervention and extracted data related to study methods, interventions, outcomes, bias risk, and adverse events. Disagreements were resolved by discussion. Trials in any type of critically ill patients in intensive

SUBMITTER: Afshari A 

PROVIDER: S-EPMC2137061 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature