In utero environmental tobacco smoke exposure alters gene expression in lungs of adult BALB/c mice.

ABSTRACT:

Background

In utero environmental tobacco smoke (ETS) exposure exacerbates initial lung responses of adult mice to ovalbumin (OVA), a common allergen in rodent models of allergic asthma.

Objective

We tested the hypothesis that in utero ETS exposure alters expression of genes (including asthma-related and inflammatory genes) in the lungs of adult mice and that this differential expression is reflected in differential respiratory and immune responses to nontobacco allergens.

Methods

Using Affymetrix Mouse Genome 430 2.0 arrays, we examined gene expression changes in lungs of BALB/c mice exposed to ETS in utero, OVA, or saline aerosol at weeks 7-8, and OVA sensitization and challenge at weeks 11-15. Data sets were filtered by transcript p-value (< or = 0.05), false disco

SUBMITTER: Rouse RL 

PROVIDER: S-EPMC2137099 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature