Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells.

ABSTRACT: Blood vascular endothelial cells (BECs) and the developmentally related lymphatic endothelial cells (LECs) create complementary, yet distinct vascular networks. Each endothelial cell type interacts with flowing fluid and circulating cells, yet each vascular system has evolved specialized gene expression programs and thus both cell types display different phenotypes. BECs and LECs express distinct genes that are unique to their specific vascular microenvironment. Tumors also take advantage of the molecules that are expressed in these vascular systems to enhance their metastatic potential. We completed transcriptome analyses on primary cultured LECs and BECs, where each comparative set was isolated from the same individual. Differences were resolved in the expression of several major categor

SUBMITTER: Nelson GM 

PROVIDER: S-EPMC2137938 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature