Drug, dosage, activity, studies of antimalarials by physical methods--II.

ABSTRACT: Studies pertaining to drug-DNA interactions in treating a disease efficiently have taken an important place in recent times. Murthy and colleagues were active in correlating the drug activity, with physical parameters like refractivity, susceptibility, molecular electron ionization cross-section and the dosage. The molecular polarizability, diamagnetic susceptibility and molecular electron ionization cross section Q have been evaluated. An analysis of Q in the light of the data available on plasma protein binding, bio availability, Log P and half-Life show semblance of regular dependence of Q on them and hence an effort is made to bring this dependence into a regular mathematical relationship. The dosage of each drug is calculated. A critical look at the results arrived on Q and dosages re

SUBMITTER: Murthy VR 

PROVIDER: S-EPMC2139996 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature