Evidence for risk of bias in cluster randomised trials: review of recent trials published in three general medical journals.

ABSTRACT:

Objective

To examine the prevalence of a risk of bias associated with the design and conduct of cluster randomised controlled trials among a sample of recently published studies.

Design

Retrospective review of cluster randomised trials published in the BMJ, Lancet, and New England Journal of Medicine from January 1997 to October 2002.

Main outcome measures

Prevalence of secure randomisation of clusters, identification of participants before randomisation (to avoid foreknowledge of allocation), differential recruitment between treatment arms, differential application of inclusion and exclusion criteria, and differential attrition.

Results

Of the 36 trials identified, 24 were published in the BMJ,11 in the Lancet, and a single trial in the New England Journal of

SUBMITTER: Puffer S 

PROVIDER: S-EPMC214092 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature