Soluble factors mediate competitive and cooperative interactions between cells expressing different levels of Drosophila Myc.

ABSTRACT: When neighboring cells in the developing Drosophila wing express different levels of the transcription factor, dMyc, competitive interactions can occur. Cells with more dMyc proliferate and ultimately overpopulate the wing, whereas cells with less dMyc die, thereby preventing wing overgrowth. How cells sense dMyc activity differences between themselves and the nature of the process leading to changes in growth and survival during competition remain unknown. We have developed a cell culture-based assay by using Drosophila S2 cells to investigate the mechanism of cell competition. We find that in vitro coculture of S2 cells that express different levels of dMyc leads to cellular interactions that recapitulate many aspects of cell competition in the developing wing. Our data indicate that bot

SUBMITTER: Senoo-Matsuda N 

PROVIDER: S-EPMC2141813 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature