Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles.

ABSTRACT: Although temporal coding is a frequent topic of neurophysiology research, trial-to-trial variability in temporal codes is typically dismissed as noise and thought to play no role in sensory function. Here, we show that much of this supposed "noise" faithfully reflects stimulus-related processes carried out in coherent neural networks. Cortical neurons responded to sensory stimuli by progressing through sequences of states, identifiable only in examinations of simultaneously recorded ensembles. The specific times at which ensembles transitioned from state to state varied from trial to trial, but the state sequences were reliable and stimulus-specific. Thus, the characterization of ensemble responses in terms of state sequences captured facets of sensory processing that are missing from, and

SUBMITTER: Jones LM 

PROVIDER: S-EPMC2141852 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature