Global analysis of host response to induction of a latent bacteriophage.

ABSTRACT:

Background

The transition from viral latency to lytic growth involves complex interactions among host and viral factors, and the extent to which host physiology is buffered from the virus during induction of lysis is not known. A reasonable hypothesis is that the virus should be evolutionarily selected to ensure host health throughout induction to minimize its chance of reproductive failure. To address this question, we collected transcriptional profiles of Escherichia coli and bacteriophage lambda throughout lysogenic induction by UV light.

Results

We observed a temporally coordinated program of phage gene expression, with distinct early, middle and late transcriptional classes. Our study confirmed known host-phage interactions of induction of the heat shock regulon, escape

SUBMITTER: Osterhout RE 

PROVIDER: S-EPMC2147009 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature