Mannitol as adjunct therapy for childhood cerebral malaria in Uganda: a randomized clinical trial.

ABSTRACT:

Background

Several reports have suggested that raised intracranial pressure (ICP) is a major contributor to death among children with cerebral malaria. Mannitol, an osmotic diuretic, effectively lowers ICP and is used to treat post-traumatic raised ICP. It is not clear whether intravenous mannitol given to children with cerebral malaria improves clinical outcome. The objective of this study was to determine the effect of mannitol as adjunct therapy on the clinical outcome of children with cerebral malaria.

Methods

This randomized double-blind placebo controlled clinical trial was carried out at the Emergency Paediatric ward of Mulago Hospital, Uganda's national referral and teaching hospital. One hundred and fifty six children aged 6 to 60 months with cerebral malaria were r

SUBMITTER: Namutangula B 

PROVIDER: S-EPMC2147028 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature