Functional polymorphisms in the promoter regions of MMP2 and MMP3 are not associated with melanoma progression.

ABSTRACT:

Background

The matrix metalloproteinases (MMPs) are enzymes that cleave various components of the extracellular matrix (ECM) and basement membranes. MMPs are expressed in melanocytes and their overexpression has been linked to tumor development, progression and metastasis. At the genetic level, the following functional promoter polymorphisms are known to modify the gene transcription: -1306 C/T and -735 C/T in the MMP2 gene, and -1171 5A/6A in the MMP3 gene. Functional polymorphisms in MMP genes' promoter regions may modulate the risk for melanoma progression.

Methods

We evaluated MMP2 and MMP3 germline polymorphisms in a group of 1002 melanoma patients using PCR-based methods, including fragment size analysis and melting temperature profiles. Two-sided Chi-Square, Cochran-A

SUBMITTER: Cotignola J 

PROVIDER: S-EPMC2148054 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature