Fasting induces a biphasic adaptive metabolic response in murine small intestine.

ABSTRACT:

Background

The gut is a major energy consumer, but a comprehensive overview of the adaptive response to fasting is lacking. Gene-expression profiling, pathway analysis, and immunohistochemistry were therefore carried out on mouse small intestine after 0, 12, 24, and 72 hours of fasting.

Results

Intestinal weight declined to 50% of control, but this loss of tissue mass was distributed proportionally among the gut's structural components, so that the microarrays' tissue base remained unaffected. Unsupervised hierarchical clustering of the microarrays revealed that the successive time points separated into distinct branches. Pathway analysis depicted a pronounced, but transient early response that peaked at 12 hours, and a late response that became progressively more pronounced

SUBMITTER: Sokolovic M 

PROVIDER: S-EPMC2148066 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature