MiR-10 represses HoxB1a and HoxB3a in zebrafish.

ABSTRACT:

Background

The Hox genes are involved in patterning the anterior-posterior axis. In addition to the protein coding Hox genes, the miR-10, miR-196 and miR-615 families of microRNA genes are conserved within the vertebrate Hox clusters. The members of the miR-10 family are located at positions associated with Hox-4 paralogues. No function is yet known for this microRNA family but the genomic positions of its members suggest a role in anterior-posterior patterning.

Methodology/principal findings

Using sensor constructs, overexpression and morpholino knockdown, we show in Zebrafish that miR-10 targets HoxB1a and HoxB3a and synergizes with HoxB4 in the repression of these target genes. Overexpression of miR-10 also induces specific phenotypes related to the loss of function of th

SUBMITTER: Woltering JM 

PROVIDER: S-EPMC2148072 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature