Wing blister, a new Drosophila laminin alpha chain required for cell adhesion and migration during embryonic and imaginal development.

ABSTRACT: We report the molecular and functional characterization of a new alpha chain of laminin in Drosophila. The new laminin chain appears to be the Drosophila counterpart of both vertebrate alpha2 (also called merosin) and alpha1 chains, with a slightly higher degree of homology to alpha2, suggesting that this chain is an ancestral version of both alpha1 and alpha2 chains. During embryogenesis, the protein is associated with basement membranes of the digestive system and muscle attachment sites, and during larval stage it is found in a specific pattern in wing and eye discs. The gene is assigned to a locus called wing blister (wb), which is essential for embryonic viability. Embryonic phenotypes include twisted germbands and fewer pericardial cells, resulting in gaps in the presumptive heart an

SUBMITTER: Martin D 

PROVIDER: S-EPMC2148222 | biostudies-literature | 1999 Apr

REPOSITORIES: biostudies-literature