Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45.

ABSTRACT: Skeletal muscle constitutes approximately 40% of the human body mass, and alterations in muscle mass and strength may result in physical disability. Therefore, the elucidation of the factors responsible for muscle force development is of paramount importance. Excitation-contraction coupling (ECC) is a process during which the skeletal muscle surface membrane is depolarized, causing a transient release of calcium from the sarcoplasmic reticulum that activates the contractile proteins. The ECC machinery is complex, and the functional role of many of its protein components remains elusive. This study demonstrates that deletion of the gene encoding the sarcoplasmic reticulum protein JP45 results in decreased muscle strength in young mice. Specifically, this loss of muscle strength in JP45 knoc

SUBMITTER: Delbono O 

PROVIDER: S-EPMC2148430 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature