SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.

ABSTRACT: G protein-coupled receptors trigger the reorganization of the actin cytoskeleton in many cell types, but the steps in this signal transduction cascade are poorly understood. During Dictyostelium development, extracellular cAMP functions as a chemoattractant and morphogenetic signal that is transduced via a family of G protein-coupled receptors, the cARs. In a strain where the cAR2 receptor gene is disrupted by homologous recombination, the developmental program arrests before tip formation. In a genetic screen for suppressors of this phenotype, a gene encoding a protein related to the Wiskott-Aldrich Syndrome protein was discovered. Loss of this protein, which we call SCAR (suppressor of cAR), restores tip formation and most later development to cAR2(-) strains, and causes a multiple-tip p

SUBMITTER: Bear JE 

PROVIDER: S-EPMC2149354 | biostudies-literature | 1998 Sep

REPOSITORIES: biostudies-literature