Ontology highlight
ABSTRACT:
SUBMITTER: Navarro-Costa P
PROVIDER: S-EPMC2151955 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Navarro-Costa Paulo P Pereira Luísa L Alves Cíntia C Gusmão Leonor L Proença Carmen C Marques-Vidal Pedro P Rocha Tiago T Correia Sónia C SC Jorge Sónia S Neves António A Soares Ana P AP Nunes Joaquim J Calhaz-Jorge Carlos C Amorim António A Plancha Carlos E CE Gonçalves João J
BMC genomics 20070928
<h4>Background</h4>The AZFc region of the human Y chromosome is a highly recombinogenic locus containing multi-copy male fertility genes located in repeated DNA blocks (amplicons). These AZFc gene families exhibit slight sequence variations between copies which are considered to have functional relevance. Yet, partial AZFc deletions yield phenotypes ranging from normospermia to azoospermia, thwarting definite conclusions on their real impact on fertility.<h4>Results</h4>The amplicon content of p ...[more]