Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.

ABSTRACT:

Objective

The normal structure and function of articular cartilage are the result of a precisely balanced interaction between anabolic and catabolic processes. The transforming growth factor-beta (TGF-beta) family of growth factors generally exerts an anabolic or repair response; in contrast, proinflammatory cytokines such as interleukin 1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) exert a strong catabolic effect. Recent evidence has shown that IL-1beta, and TNF-alpha, and the TGF-beta signaling pathways share an antagonistic relationship. The aim of this study was to determine whether the modulation of the response of articular chondrocytes to TGF-beta by IL-1beta or TNF-alpha signaling pathways occurs through regulation of activity and availability of mothers aga

SUBMITTER: Roman-Blas JA 

PROVIDER: S-EPMC2153443 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature