Possible use of repeated cold stress for reducing fatigue in chronic fatigue syndrome: a hypothesis.

ABSTRACT:

Background

Physiological fatigue can be defined as a reduction in the force output and/or energy-generating capacity of skeletal muscle after exertion, which may manifest itself as an inability to continue exercise or usual activities at the same intensity. A typical example of a fatigue-related disorder is chronic fatigue syndrome (CFS), a disabling condition of unknown etiology and with uncertain therapeutic options. Recent advances in elucidating pathophysiology of this disorder revealed hypofunction of the hypothalamic-pituitary-adrenal axis and that fatigue in CFS patients appears to be associated with reduced motor neurotransmission in the central nervous system (CNS) and to a smaller extent with increased fatigability of skeletal muscle. There is also some limited evidence t

SUBMITTER: Shevchuk NA 

PROVIDER: S-EPMC2164952 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature