Role of Streptococcus gordonii surface proteins SspA/SspB and Hsa in platelet function.

ABSTRACT: Streptococcus gordonii colonization of damaged heart surfaces in infective endocarditis is dependent upon the recognition of host receptors by specific bacterial surface proteins. However, despite several attempts to identify the mechanisms involved in this interaction, the nature of the bacterial proteins required remains poorly understood. This study provides clear evidence that several S. gordonii surface proteins participate in the interaction with platelets to support platelet adhesion and induce platelet aggregation. S. gordonii strains were found to support strong (DL1-Challis, SK12, SK184, and Blackburn) or moderate (UB1545 delta hsa and CH1-Challis) adhesion or failed to support platelet adhesion (M5, M99, and Channon). In addition, under flow conditions, platelets rolled and subs

SUBMITTER: Kerrigan SW 

PROVIDER: S-EPMC2168320 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature