In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized.

ABSTRACT: At least a million people, mainly African children under 5 years old, still die yearly from malaria, and the burden of disease and death has increased. Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is one of the most promising blood-stage malarial vaccine candidates. However, the allelic polymorphism observed in this protein is a potential stumbling block for vaccine development. To overcome the polymorphism- and strain-specific growth inhibition in vitro, we previously showed in a rabbit model that vaccination with a mixture of two allelic forms of PfAMA1 induced parasite growth-inhibitory antisera against both strains of P. falciparum parasites in vitro. In the present study, we have established that, in contrast to a single-allele protein, the antigen mixture elicits primaril

SUBMITTER: Miura K 

PROVIDER: S-EPMC2168362 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature