Genome-wide transcriptional changes in Streptococcus gordonii in response to competence signaling peptide.

ABSTRACT: Streptococcus gordonii is a primary colonizer of the multispecies biofilm on tooth surfaces forming dental plaque and a potential agent of endocarditis. The recent completion of the genome sequence of the naturally competent strain Challis allowed the design of a spotted oligonucleotide microarray to examine a genome-wide response of this organism to environmental stimuli such as signal peptides. Based on temporal responses to synthetic competence signaling peptide (CSP) as indicated by transformation frequencies, the S. gordonii transcriptome was analyzed at various time points after CSP exposure. Microarray analysis identified 35 candidate early genes and 127 candidate late genes that were up-regulated at 5 and 15 min, respectively; these genes were often grouped in clusters. Results sup

SUBMITTER: Vickerman MM 

PROVIDER: S-EPMC2168715 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature