Defining the stressome of Mycobacterium avium subsp. paratuberculosis in vitro and in naturally infected cows.

ABSTRACT: Mycobacterium avium subsp. paratuberculosis causes an enteric infection in cattle, with a great impact on the dairy industry in the United States and worldwide. Characterizing the gene expression profile of M. avium subsp. paratuberculosis exposed to different stress conditions, or shed in cow feces, could improve our understanding of the pathogenesis of M. avium subsp. paratuberculosis. In this report, the stress response of M. avium subsp. paratuberculosis on a genome-wide level (stressome) was defined for the first time using DNA microarrays. Expression data analysis revealed unique gene groups of M. avium subsp. paratuberculosis that were regulated under in vitro stressors while additional groups were regulated in the cow samples. Interestingly, acidic pH induced the regulation of a la

SUBMITTER: Wu CW 

PROVIDER: S-EPMC2168719 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature