Differential control of Wnt target genes involves epigenetic mechanisms and selective promoter occupancy by T-cell factors.

ABSTRACT: Canonical Wnt signaling and its nuclear effectors, beta-catenin and the family of T-cell factor (TCF) DNA-binding proteins, belong to the small number of regulatory systems which are repeatedly used for context-dependent control of distinct genetic programs. The apparent ability to elicit a large variety of transcriptional responses necessitates that beta-catenin and TCFs distinguish precisely between genes to be activated and genes to remain silent in a specific context. How this is achieved is unclear. Here, we examined patterns of Wnt target gene activation and promoter occupancy by TCFs in different mouse cell culture models. Remarkably, within a given cell type only Wnt-responsive promoters are bound by specific subsets of TCFs, whereas nonresponsive Wnt target promoters remain unoccu

SUBMITTER: Wohrle S 

PROVIDER: S-EPMC2169180 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature