IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease.

ABSTRACT:

Background

The IL-23 receptor (IL-23R) has been found to be associated with small bowel Crohn's disease (CD) in a whole genome association study. Specifically, the rare allele of the R381Q single nucleotide polymorphism (SNP) conferred protection against CD. It is unknown whether IL-23R is associated with IBD in children. The aim was to examine the association of IL-23R with susceptibility to IBD in pediatric patients.

Methods

DNA was collected from 609 subjects (151 CD and 52 ulcerative colitis [UC] trios). Trios were genotyped for the R381Q SNP of the IL-23R gene and SNP8, SNP12, SNP13, of the CARD15 gene using Taqman. The transmission disequilibrium test (TDT) was used for association to disease using GENEHUNTER 2.0.

Results

The rare allele of R381Q SNP was present

SUBMITTER: Dubinsky MC 

PROVIDER: S-EPMC2169293 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature