Trypanin is a cytoskeletal linker protein and is required for cell motility in African trypanosomes.

ABSTRACT: The cytoskeleton of eukaryotic cells is comprised of a complex network of distinct but interconnected filament systems that function in cell division, cell motility, and subcellular trafficking of proteins and organelles. A gap in our understanding of this dynamic network is the identification of proteins that connect subsets of cytoskeletal structures. We previously discovered a family of cytoskeleton-associated proteins that includes GAS11, a candidate human tumor suppressor upregulated in growth-arrested cells, and trypanin, a component of the flagellar cytoskeleton of African trypanosomes. Although these proteins are intimately associated with the cytoskeleton, their function has yet to be determined. Here we use double-stranded RNA interference to block trypanin expression in Trypanos

SUBMITTER: Hutchings NR 

PROVIDER: S-EPMC2173309 | biostudies-literature | 2002 Mar

REPOSITORIES: biostudies-literature