Focal loss of actin bundles causes microtubule redistribution and growth cone turning.

ABSTRACT: It is commonly believed that growth cone turning during pathfinding is initiated by reorganization of actin filaments in response to guidance cues, which then affects microtubule structure to complete the turning process. However, a major unanswered question is how changes in actin cytoskeleton are induced by guidance cues and how these changes are then translated into microtubule rearrangement. Here, we report that local and specific disruption of actin bundles from the growth cone peripheral domain induced repulsive growth cone turning. Meanwhile, dynamic microtubules within the peripheral domain were oriented into areas where actin bundles remained and were lost from areas where actin bundles disappeared. This resulted in directional microtubule extension leading to axon bending and gro

SUBMITTER: Zhou FQ 

PROVIDER: S-EPMC2173410 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature