Choke point analysis of metabolic pathways in E.histolytica: a computational approach for drug target identification.

ABSTRACT: With the Entamoeba genome essentially complete, the organism can be studied from a whole genome standpoint. The understanding of cellular mechanisms and interactions between cellular components is instrumental to the development of new effective drugs and vaccines. Metabolic pathway analysis is becoming increasingly important for assessing inherent network properties in reconstructed biochemical reaction networks. Metabolic pathways illustrate how proteins work in concert to produce cellular compounds or to transmit information at different levels. Identification of drug targets in E. histolytica through metabolic pathway analysis promises to be a novel approach in this direction. This article focuses on the identification of drug targets by subjecting the Entamoeba genome to BLAST with th

SUBMITTER: Singh S 

PROVIDER: S-EPMC2174424 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature