Sequences conserved by selection across mouse and human malaria species.

ABSTRACT:

Unlabelled

Little is known, either experimentally or computationally, about the genomic sequence features that regulate malaria genes. A sequence conservation analysis of the malaria species P. falciparum, P. berghei, P. yoelii, and P. chabaudi could significantly advance knowledge of malaria gene regulation.

Results

We computationally identify intergenic sequences conserved beyond neutral expectations, using a conservation algorithm that accounts for the strong compositional biases in malaria genomes. We first quantify the composition-specific divergence at silent positions in coding sequence. Using this as a background, we examine gene 5' regions, identifying 610 blocks conserved far beyond neutral expectations across the three mouse malariae, and 81 blocks conserved as st

SUBMITTER: Imamura H 

PROVIDER: S-EPMC2174483 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature