Coordination logic of the sensing machinery in the transcriptional regulatory network of Escherichia coli.

ABSTRACT: The active and inactive state of transcription factors in growing cells is usually directed by allosteric physicochemical signals or metabolites, which are in turn either produced in the cell or obtained from the environment by the activity of the products of effector genes. To understand the regulatory dynamics and to improve our knowledge about how transcription factors (TFs) respond to endogenous and exogenous signals in the bacterial model, Escherichia coli, we previously proposed to classify TFs into external, internal and hybrid sensing classes depending on the source of their allosteric or equivalent metabolite. Here we analyze how a cell uses its topological structures in the context of sensing machinery and show that, while feed forward loops (FFLs) tightly integrate internal and

SUBMITTER: Janga SC 

PROVIDER: S-EPMC2175315 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature