Functional genomic delineation of TLR-induced transcriptional networks.

ABSTRACT:

Background

The innate immune system is the first line of defense mechanisms protecting the host from invading pathogens such as bacteria and viruses. The innate immunity responses are triggered by recognition of prototypical pathogen components by cellular receptors. Prominent among these pathogen sensors are Toll-like receptors (TLRs). We sought global delineation of transcriptional networks induced by TLRs, analyzing four genome-wide expression datasets in mouse and human macrophages stimulated with pathogen-mimetic agents that engage various TLRs.

Results

Combining computational analysis of expression profiles and cis-regulatory promoter sequences, we dissected the TLR-induced transcriptional program into two major components: the first is universally activated by all exa

SUBMITTER: Elkon R 

PROVIDER: S-EPMC2175519 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature