Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway.

ABSTRACT:

Background

We recently described a genomic pathway approach to study complex diseases. We demonstrated that models constructed using single nucleotide polymorphisms (SNPs) within axon guidance pathway genes were highly predictive of Parkinson disease (PD) susceptibility, survival free of PD, and age at onset of PD within two independent whole-genome association datasets. We also demonstrated that several axon guidance pathway genes represented by SNPs within our final models were differentially expressed in PD.

Methodology/principal findings

Here we employed our genomic pathway approach to analyze data from a whole-genome association dataset of amyotrophic lateral sclerosis (ALS); and demonstrated that models constructed using SNPs within axon guidance pathway genes were hig

SUBMITTER: Lesnick TG 

PROVIDER: S-EPMC2175528 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature