Alcohol ingestion by donors amplifies experimental airway disease after heterotopic transplantation.

ABSTRACT:

Rationale

Obliterative bronchiolitis (OB) after lung transplantation is triggered by alloimmunity, but is ultimately mediated by transforming growth factor (TGF)-beta(1)-dependent airway fibrosis.

Objectives

Chronic alcohol use increases TGF-beta(1) expression and renders the lung susceptible to injury. Therefore, we hypothesized that donor alcohol abuse could prime the lung allograft for OB, as many organ donors have a history of alcohol abuse.

Methods

Tracheas from control and alcohol-fed rats (8 wk) were heterotopically transplanted into recipients with varying degrees of alloimmune mismatch and analyzed for obliterative airway disease severity on Postoperative Day 21.

Measurements and main results

Although donor alcohol ingestion did not increase the number

SUBMITTER: Mitchell PO 

PROVIDER: S-EPMC2176096 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature