Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.

ABSTRACT:

Rationale

High-dose ibuprofen in a 4-year controlled trial slowed FEV(1) decline in young subjects with cystic fibrosis, but the effectiveness of ibuprofen has not been assessed in a large group of patients treated clinically with this therapy.

Objectives

To assess the effect of ibuprofen therapy on FEV(1) decline in children and adolescents with cystic fibrosis, using observational data from the Cystic Fibrosis Foundation Patient Registry.

Methods

The rate of decline in FEV(1) percent predicted over 2-7 years among patients age 6-17 years with FEV(1) > 60% predicted, and who were treated with ibuprofen (1,365), was compared with patients of similar age and disease severity who were not treated with this therapy (8,960). Multilevel repeated-measures mixed-regression m

SUBMITTER: Konstan MW 

PROVIDER: S-EPMC2176097 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature