Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates.

ABSTRACT:

Rationale

Associations between oligomeric isocyanate exposure, sensitization, and respiratory disease have received little attention, despite the extensive use of isocyanate oligomers.

Objectives

To investigate exposure-response relationships of respiratory symptoms and sensitization in a large population occupationally exposed to isocyanate oligomers during spray painting.

Methods

The prevalence of respiratory symptoms and sensitization was assessed in 581 workers in the spray-painting industry. Personal exposure was estimated by combining personal task-based inhalatory exposure measurements and time activity information. Specific IgE and IgG to hexamethylene diisocyanate (HDI) were assessed in serum by ImmunoCAP assay and enzyme immunoassays using vapor and liquid p

SUBMITTER: Pronk A 

PROVIDER: S-EPMC2176099 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature