Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.

ABSTRACT:

Rationale

Nitric oxide-independent agonists of soluble guanylate cyclase (sGC) have been developed.

Objectives

We tested whether inhalation of novel dry-powder microparticle formulations containing sGC stimulators (BAY 41-2272, BAY 41-8543) or an sGC activator (BAY 58-2667) would produce selective pulmonary vasodilation in lambs with acute pulmonary hypertension. We also evaluated the combined administration of BAY 41-8543 microparticles and inhaled nitric oxide (iNO). Finally, we examined whether inhaling BAY 58-2667 microparticles would produce pulmonary vasodilation when the response to iNO is impaired.

Methods

In awake, spontaneously breathing lambs instrumented with vascular catheters and a tracheostomy tube, U-46619 was infused intravenously to increase mean pul

SUBMITTER: Evgenov OV 

PROVIDER: S-EPMC2176100 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature