Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma.

ABSTRACT:

Rationale

Transforming growth factor (TGF)-beta1 is involved in airway inflammation and remodeling, two key processes in asthma pathogenesis. Tobacco smoke and traffic emissions induce airway inflammation and modulate TGF-beta1 gene expression. We hypothesized that the effects of functional TGF-beta1 variants on asthma occurrence vary by these exposures.

Objectives

We tested these hypotheses among 3,023 children who participated in the Children's Health Study.

Methods

Tagging single-nucleotide polymorphisms rs4803457 C>T and C-509T (a functional promoter polymorphism) accounted for 94% of the haplotype diversity of the upstream region. Exposure to maternal smoking in utero was based on smoking by biological mother during pregnancy. Residential distance from nearest fr

SUBMITTER: Salam MT 

PROVIDER: S-EPMC2176104 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature