Colorectal cancer risks in relatives of young-onset cases: is risk the same across all first-degree relatives?

ABSTRACT:

Background & aims

During the last 15 years, several single-gene mendelian disorders have been discovered that might account for some of the familial aggregation detected in large population studies of colorectal cancer (CRC). Mutations in DNA mismatch repair (MMR) genes cause hereditary nonpolyposis colorectal cancer-Lynch syndrome, the most common of the recognized CRC-predisposition syndromes, in which one major feature is a young age for cancer onset. However, for young-onset microsatellite stable (MSS) CRC, the familial risk for CRC is unknown.

Methods

Patients with CRC who were <50 years old were identified through Minnesota Cancer Surveillance System (MCSS) and Mayo Clinic, Rochester, MN. CRCs in which the DNA MMR function was deficient as evidenced by high level micro

SUBMITTER: Boardman LA 

PROVIDER: S-EPMC2180165 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature