The Basic Immune Simulator: an agent-based model to study the interactions between innate and adaptive immunity.

ABSTRACT:

Background

We introduce the Basic Immune Simulator (BIS), an agent-based model created to study the interactions between the cells of the innate and adaptive immune system. Innate immunity, the initial host response to a pathogen, generally precedes adaptive immunity, which generates immune memory for an antigen. The BIS simulates basic cell types, mediators and antibodies, and consists of three virtual spaces representing parenchymal tissue, secondary lymphoid tissue and the lymphatic/humoral circulation. The BIS includes a Graphical User Interface (GUI) to facilitate its use as an educational and research tool.

Results

The BIS was used to qualitatively examine the innate and adaptive interactions of the immune response to a viral infection. Calibration was accomplished via

SUBMITTER: Folcik VA 

PROVIDER: S-EPMC2186321 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature