Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

ABSTRACT:

Context

Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined.

Objective

The objective of this study was to evaluate previously associated variants for association with measures of glucose homeostasis in Hispanic-Americans and African-Americans and determine the biological mechanism(s) through which these variants exert their effect.

Design

This study was the Insulin Resistance Atherosclerosis Family Study (IRAS-FS).

Setting

The IRAS-FS is a community-based study of Hispanic-Americans (San Antonio, TX, and San Luis Valley, CO) and African-Americans (Los Angeles, CA).

Participants

A total of 1040 Hisp

SUBMITTER: Palmer ND 

PROVIDER: S-EPMC2190750 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature