Relationship of fat distribution with adipokines in human immunodeficiency virus infection.

ABSTRACT:

Background and methods

HIV-infected patients receiving antiretroviral therapy often develop changes in body fat distribution; the dominant change is reduction in sc adipose tissue (SAT). Because adipose tissue makes important hormones involved in whole-body energy metabolism, including leptin and adiponectin, we examined plasma concentrations and their relationship to regional adiposity measured by magnetic resonance imaging in 1143 HIV-infected persons (803 men and 340 women) and 286 controls (151 men and 135 women) in a cross-sectional analysis of the FRAM study.

Results

Total and regional adiposity correlated positively with leptin levels in HIV-infected subjects and controls (P < 0.0001). In controls, total and regional adiposity correlated negatively with adiponectin. I

SUBMITTER: Kosmiski LA 

PROVIDER: S-EPMC2190751 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature