Ontology highlight
ABSTRACT:
SUBMITTER: Sims JE
PROVIDER: S-EPMC2193273 | biostudies-literature | 2000 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20000901 5
Using a bioassay consisting of the proliferation of a murine B cell line, a cDNA of a gene whose product supports the growth of that cell line was isolated from a thymic stromal cell line. This factor, termed thymic stromal lymphopoietin (TSLP), is a protein of 140 amino acids. The gene encoding TSLP was mapped to murine chromosome 18. Purified recombinant TSLP supported the growth of pre-B cell colonies in vitro, but had no myelopoietic activity. TSLP had comitogenic activity for fetal thymocyt ...[more]