Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7.

ABSTRACT:

Background

In the mammalian genome, a substantial number of gene pairs (approximately 10%) are arranged head-to-head on opposite strands within 1,000 base pairs, and separated by a bidirectional promoter(s) that generally drives the co-expression of both genes and results in functional coupling. The significance of unique genomic configuration remains elusive.

Methodology/principal findings

Here we report on the identification of an intergenic region of non-homologous genes, CDT2, a regulator of DNA replication, and an integrator complex subunit 7 (INTS7), an interactor of the largest subunit of RNA polymerase II. The CDT2-INTS7 intergenic region is 246 and 245 base pairs long in human and mouse respectively and is evolutionary well-conserved among several mammalian species.

SUBMITTER: Nakagawa H 

PROVIDER: S-EPMC2194621 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature