Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles.

ABSTRACT: Toxicogenomics can measure the expression of thousands of genes to identify changes associated with drug induced toxicities. It is expected that toxicogenomics can be an alternative or complementary approach in preclinical drug safety evaluation to identify or predict drug induced toxicities. One of the major concerns in applying toxicogenomics to diagnose or predict drug induced organ toxicity, is how generalizable the statistical classification model is when derived from small datasets? Here we presented that a diagnosis of kidney proximal tubule toxicity, measured by pathology, can successfully be achieved even with a study design of limited number of training studies or samples. We selected a total of ten kidney toxicants, designed the in life study with multiple dose and multiple time

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC2194664 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature