Detection of regulatory circuits by integrating the cellular networks of protein-protein interactions and transcription regulation.

ABSTRACT: The post-genomic era is marked by huge amounts of data generated by large-scale functional genomic and proteomic experiments. A major challenge is to integrate the various types of genome-scale information in order to reveal the intra- and inter- relationships between genes and proteins that constitute a living cell. Here we present a novel application of classical graph algorithms to integrate the cellular networks of protein-protein interactions and transcription regulation. We demonstrate how integration of these two networks enables the discovery of simple as well as complex regulatory circuits that involve both protein-protein and protein-DNA interactions. These circuits may serve for positive or negative feedback mechanisms. By applying our approach to data from the yeast Saccharomyc

SUBMITTER: Yeger-Lotem E 

PROVIDER: S-EPMC219468 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature