A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion.

ABSTRACT:

Background

Altered gene expression is an important feature of ischemic cerebral injury and affects proteins of many functional classes. We have used microarrays to investigate the changes in gene expression at various times after middle cerebral artery occlusion in human and rat brain.

Results

Our results demonstrated a significant difference in the number of genes affected and the time-course of expression between the two cases. The total number of deregulated genes in the rat was 335 versus 126 in the human, while, of 393 overlapping genes between the two array sets, 184 were changed only in the rat and 36 in the human with a total of 41 genes deregulated in both cases. Interestingly, the mean fold changes were much higher in the human. The expression of novel genes, inclu

SUBMITTER: Mitsios N 

PROVIDER: S-EPMC2194693 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature