Computational selection and prioritization of candidate genes for fetal alcohol syndrome.

ABSTRACT:

Background

Fetal alcohol syndrome (FAS) is a serious global health problem and is observed at high frequencies in certain South African communities. Although in utero alcohol exposure is the primary trigger, there is evidence for genetic- and other susceptibility factors in FAS development. No genome-wide association or linkage studies have been performed for FAS, making computational selection and -prioritization of candidate disease genes an attractive approach.

Results

10174 Candidate genes were initially selected from the whole genome using a previously described method, which selects candidate genes according to their expression in disease-affected tissues. Hereafter candidates were prioritized for experimental investigation by investigating criteria pertinent to FAS an

SUBMITTER: Lombard Z 

PROVIDER: S-EPMC2194724 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature